Missing genes in metabolic pathways: a comparative genomics approach.

Osterman A, Overbeek R.

The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.

Curr Opin Chem Biol. 2003 Apr;7(2):238-51.